A redox-based electrogenetic CRISPR system to connect with and control biological information networks

Narendranath Bhokisham; Eric VanArsdale; Kristina T. Stephens; Pricila Hauk; Gregory F. Payne; William E. Bentley

doi:10.1038/s41467-020-16249-x

Nature Communications (May 2020)

A redox-based electrogenetic CRISPR system to connect with and control biological information networks

Narendranath Bhokisham,
Eric VanArsdale,
Kristina T. Stephens,
Pricila Hauk,
Gregory F. Payne,
William E. Bentley

Affiliations

Narendranath Bhokisham: Biological Sciences Graduate Program—College of Computer, Mathematical and Natural Sciences, University of Maryland
Eric VanArsdale: Institute of Bioscience and Biotechnology Research, University of Maryland
Kristina T. Stephens: Institute of Bioscience and Biotechnology Research, University of Maryland
Pricila Hauk: Institute of Bioscience and Biotechnology Research, University of Maryland
Gregory F. Payne: Institute of Bioscience and Biotechnology Research, University of Maryland
William E. Bentley: Institute of Bioscience and Biotechnology Research, University of Maryland

DOI: https://doi.org/10.1038/s41467-020-16249-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Redox-responsive transcriptional regulators can enable user-specified electronic control over biological functions. Here the authors demonstrate electronic control of CRISPRa and CRISPRi using redox signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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