Nature Communications (Sep 2017)
Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
- Xi-Xi Chen,
- Qian Zhong,
- Yang Liu,
- Shu-Mei Yan,
- Zhang-Hua Chen,
- Shan-Zhao Jin,
- Tian-Liang Xia,
- Ruo-Yan Li,
- Ai-Jun Zhou,
- Zhe Su,
- Yu-Hua Huang,
- Qi-Tao Huang,
- Li-Yun Huang,
- Xing Zhang,
- Yan-Na Zhao,
- Jin-Ping Yun,
- Qiu-Liang Wu,
- Dong-Xin Lin,
- Fan Bai,
- Mu-Sheng Zeng
Affiliations
- Xi-Xi Chen
- Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Qian Zhong
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Yang Liu
- Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Shu-Mei Yan
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Zhang-Hua Chen
- Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Shan-Zhao Jin
- Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Tian-Liang Xia
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Ruo-Yan Li
- Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Ai-Jun Zhou
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Zhe Su
- Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Yu-Hua Huang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Qi-Tao Huang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Li-Yun Huang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Xing Zhang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Yan-Na Zhao
- Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Jin-Ping Yun
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Qiu-Liang Wu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Dong-Xin Lin
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Fan Bai
- Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Mu-Sheng Zeng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- DOI
- https://doi.org/10.1038/s41467-017-00650-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
The pathogenesis of oesophageal squamous cell carcinoma is a multi-step process but the genetic determinants behind this progression are unknown. Here the authors use multi-region exome sequencing to comprehensively investigate the genetic evolution of precursor dysplastic lesions and untransformed oesophagus.
