Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct

Luis A. Ortiz-Rodríguez; Christian Reichardt; Sean J. Hoehn; Steffen Jockusch; Carlos E. Crespo-Hernández

doi:10.1038/s41467-020-17333-y

Nature Communications (Jul 2020)

Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct

Luis A. Ortiz-Rodríguez,
Christian Reichardt,
Sean J. Hoehn,
Steffen Jockusch,
Carlos E. Crespo-Hernández

Affiliations

Luis A. Ortiz-Rodríguez: Department of Chemistry, Case Western Reserve University
Christian Reichardt: Department of Chemistry, Case Western Reserve University
Sean J. Hoehn: Department of Chemistry, Case Western Reserve University
Steffen Jockusch: Department of Chemistry, Columbia University
Carlos E. Crespo-Hernández: Department of Chemistry, Case Western Reserve University

DOI: https://doi.org/10.1038/s41467-020-17333-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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The mechanisms of formation of the (6-4) photoproducts in DNA damage by sunlight is still debated. Here the authors show, by optical spectroscopies and computations, the details of the formation of a (6-4) photoadduct via the thietane intermediate in a single-stranded DNA oligonucleotide.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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