Journal of Biological Research (Jan 2011)

Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction

  • D. Palmieri,
  • C. Barisione,
  • C, Pane,
  • G. Spinella,
  • S. Garibaldi,
  • G. Ghigliotti,
  • C. Brunelli,
  • E. Fulcheri,
  • D. Palombo

DOI
https://doi.org/10.4081/jbr.2011.4638
Journal volume & issue
Vol. 84, no. 1

Abstract

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Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L-monocyte subset, monocyte CD I 43 surface expression, MMP-9 plasma activity and TNFα serum levels were lower in Rsv-treated rats. In conclusion. Rsv acts as an anti-inflammatory compound and could be of great revelance to improve the immune response in AAA patients.

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