Frontiers in Neurology (Mar 2023)
Associations of macular microvascular parameters with cerebral small vessel disease in rural older adults: A population-based OCT angiography study
- Zhe Xu,
- Yi Dong,
- Yi Dong,
- Yi Dong,
- Yongxiang Wang,
- Yongxiang Wang,
- Yongxiang Wang,
- Lin Song,
- Lin Song,
- Lin Song,
- Sijie Niu,
- Shanshan Wang,
- Shanshan Wang,
- Shanshan Wang,
- Mingqing Zhao,
- Jiafeng Wang,
- Lin Cong,
- Lin Cong,
- Lin Cong,
- Xiaojuan Han,
- Xiaojuan Han,
- Xiaojuan Han,
- Tingting Hou,
- Tingting Hou,
- Tingting Hou,
- Shi Tang,
- Shi Tang,
- Shi Tang,
- Qinghua Zhang,
- Qinghua Zhang,
- Qinghua Zhang,
- Yifeng Du,
- Yifeng Du,
- Yifeng Du,
- Chengxuan Qiu,
- Chengxuan Qiu
Affiliations
- Zhe Xu
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Yi Dong
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Yi Dong
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Yi Dong
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Yongxiang Wang
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Yongxiang Wang
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Yongxiang Wang
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Lin Song
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Lin Song
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Lin Song
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Sijie Niu
- Shandong Provincial Key Laboratory of Network Based Intelligent Computing, School of Information Science and Engineering, University of Jinan, Jinan, Shandong, China
- Shanshan Wang
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Shanshan Wang
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Shanshan Wang
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Mingqing Zhao
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Jiafeng Wang
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Lin Cong
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Lin Cong
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Lin Cong
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Xiaojuan Han
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Xiaojuan Han
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Xiaojuan Han
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Tingting Hou
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Tingting Hou
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Tingting Hou
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Shi Tang
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Shi Tang
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Shi Tang
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Qinghua Zhang
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Qinghua Zhang
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Qinghua Zhang
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Yifeng Du
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Yifeng Du
- Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Yifeng Du
- Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, China
- Chengxuan Qiu
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
- Chengxuan Qiu
- Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden
- DOI
- https://doi.org/10.3389/fneur.2023.1133819
- Journal volume & issue
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Vol. 14
Abstract
ObjectiveTo explore the associations of macular microvascular parameters with cerebral small vessel disease (CSVD) in rural-dwelling older adults in China.MethodsThis population-based cross-sectional study included 195 participants (age ≥ 60 years; 57.4% women) in the optical coherence tomographic angiography (OCTA) sub-study within the Multimodal Interventions to delay Dementia and disability in rural China (MIND-China). Macular microvascular parameters were measured using the OCTA. We automatically estimated volumes of gray matter, white matter, and white matter hyperintensity (WMH), and manually assessed numbers of enlarged perivascular spaces (EPVS) and lacunes on brain magnetic resonance imaging. Data were analyzed with the general linear models.ResultsAdjusting for multiple confounders, lower vessel skeleton density (VSD) and higher vessel diameter index (VDI) were significantly associated with larger WMH volume (P < 0.05). Lower VSD and foveal density-300 (FD-300) of left eye were significantly associated with lower brain parenchymal volume (P < 0.05). In addition, lower areas of foveal avascular zone (FAZ) and FD-300 of left eye were significantly associated with more EPVS (P < 0.05). The associations of abnormal macular microvascular parameters with WMH volume were evident mainly among females. Macular microvascular parameters were not associated with lacunes.ConclusionMacular microvascular signs are associated with WMH, brain parenchymal volume, and EPVS in older adults. The OCTA-assessed macular microvascular parameters can be valuable markers for microvascular lesions in the brain.
Keywords
- macular microvascular signs
- cerebral small vessel disease
- optical coherence tomography angiography
- magnetic resonance imaging
- population-based study
