Characterization of the <i>Sideritis scardica</i> Extract SidTea+<sup>TM</sup> and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study
Konstantinos Papanikolaou,
Konstantinos Kouloridas,
Anastasia Rosvoglou,
Athanasios Gatsas,
Kalliopi Georgakouli,
Chariklia K. Deli,
Dimitrios Draganidis,
Aikaterini Argyropoulou,
Dimitris Michailidis,
Ioannis G. Fatouros,
Athanasios Z. Jamurtas
Affiliations
Konstantinos Papanikolaou
Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Konstantinos Kouloridas
Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Anastasia Rosvoglou
Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Athanasios Gatsas
Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Kalliopi Georgakouli
Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece
Chariklia K. Deli
Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Dimitrios Draganidis
Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Aikaterini Argyropoulou
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece
Dimitris Michailidis
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece
Ioannis G. Fatouros
Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Athanasios Z. Jamurtas
Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
This study aimed to characterize a Sideritis scardica extract (SidTea+TM) and investigate its effect on the physiological profile, metabolic health and redox status in healthy individuals. The chemical profile and antioxidant potential of the SidTea+TM extract were evaluated by UPLC-HRMS analysis and in vitro cell-free methods. Twenty-eight healthy adults participated in this randomized, double-blind, placebo-controlled study. Participants consumed 1500 mg/day of SidTea+TM or a placebo for 4 weeks. At baseline and post-supplementation, participants were assessed for their anthropometric and physiological profile and provided a resting blood sample. SidTea+TM decreased (p p TM also resulted in an increase (p 2max (+1.1 mL/kg/min) and a reduction (p TM increased (p p TM is a potent and safe to use antioxidant that can elicit positive changes in indices of blood pressure, cardiorespiratory capacity, liver metabolism, and redox status in healthy adults over a 4-week supplementation period.
