Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission
Wcleubianne Matias Nascimento Maia,
Francisco Das Chagas Pereira de Andrade,
Livia Alves Filgueiras,
Anderson Nogueira Mendes,
Amanda Fonseca Costa Assunção,
Nicolas Davidson Sérvulo Rodrigues,
Rosemarie Brandim Marques,
Antônio Luiz Martins Maia Filho,
Damião Pergentino de Sousa,
Luciano Da Silva Lopes
Affiliations
Wcleubianne Matias Nascimento Maia
Postgraduate Programs in Pharmaceutical Sciences and Laboratory of Research in Experimental Neurochemistry (LAPNEX), Federal University of Piauí, 64049-550, Teresina, Brazil
Francisco Das Chagas Pereira de Andrade
Laboratory of Innovation in Science and Technology, LACITEC, Department of Biophysics and Physiology, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil
Livia Alves Filgueiras
Laboratory of Innovation in Science and Technology, LACITEC, Department of Biophysics and Physiology, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil
Anderson Nogueira Mendes
Laboratory of Innovation in Science and Technology, LACITEC, Department of Biophysics and Physiology, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil
Amanda Fonseca Costa Assunção
Nucleus of Biotechnology and Biodiversity of the State University of Piauí, 64003-120, Teresina, Piauí, Brazil
Nicolas Davidson Sérvulo Rodrigues
Nucleus of Biotechnology and Biodiversity of the State University of Piauí, 64003-120, Teresina, Piauí, Brazil
Rosemarie Brandim Marques
Nucleus of Biotechnology and Biodiversity of the State University of Piauí, 64003-120, Teresina, Piauí, Brazil
Antônio Luiz Martins Maia Filho
Nucleus of Biotechnology and Biodiversity of the State University of Piauí, 64003-120, Teresina, Piauí, Brazil
Damião Pergentino de Sousa
Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil
Luciano Da Silva Lopes
Postgraduate Programs in Pharmaceutical Sciences and Laboratory of Research in Experimental Neurochemistry (LAPNEX), Federal University of Piauí, 64049-550, Teresina, Brazil; Corresponding author.
Rose oxide (RO) is a monoterpene found in rose oil fragrances. This monoterpene has been reported to possess anti-inflammatory activity, however, little is known regarding its pharmacological activity. The present study was carried out to evaluate its antidepressant action and possible mechanisms of action. Analysis of ADMET pharmacokinetic properties (absorption, distribution, metabolism, excretion and toxicity) of rose oxide was performed by computational prediction analysis. Behavioral tests were performed to assess the interaction between rose oxide and the central nervous system and antidepressant effect that includes: forced swim test (FST), tail suspension test (TST), open field test (OFT) and rota-rod test. The results of pharmacokinetic and toxicological properties indicate that rose oxide could be used orally, since it has good intestinal absorption as well as pharmacological and toxicological properties that can be similar to pharmacological compounds (regular hepatic metabolism and low toxicity). Treatment with 50 mg/kg of rose oxide was able to decrease the immobility time of animals not affected by FST and TST and was not able to alter the motor activity of the OFT and rota-rod test, suggesting modulation and antidepressant activity. Docking data suggest that rose oxide can bind to receptors in the serotonergic pathway. The results described here suggest that rose oxide has antidepressant activity, modulating the serotonergic pathway.
