Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice

Hajime  Terao; Kazuhito  Asano; Ken-ichi  Kanai; Yoshiyuki  Kyo; So  Watanabe; Tadashi  Hisamitsu; Harumi  Suzaki

doi:10.1080/09629350310001599620

Mediators of Inflammation (Jan 2003)

Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice

Hajime Terao,
Kazuhito Asano,
Ken-ichi Kanai,
Yoshiyuki Kyo,
So Watanabe,
Tadashi Hisamitsu,
Harumi Suzaki

Affiliations

Hajime Terao: Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, Japan
Kazuhito Asano: Department of Physiology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, Japan
Ken-ichi Kanai: Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, Japan
Yoshiyuki Kyo: Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, Japan
So Watanabe: Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, Japan
Tadashi Hisamitsu: Department of Physiology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, Japan
Harumi Suzaki: Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, Japan

DOI: https://doi.org/10.1080/09629350310001599620
Journal volume & issue: Vol. 12, no. 4
pp. 195 – 202

Abstract

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Background and aim: Low-dose and long-term administration of macrolide antibiotics into patients with chronic airway inflammatory diseases could favorably modify their clinical conditions. However, the therapeutic mode of action of macrolides is not well understood. Free oxygen radicals, including nitric oxide (NO), are well recognized as the important final effector molecules in the development and the maintenance of inflammatory diseases.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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