Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites

• Kuan-Wei Huang,
• Jing-Wen Chen,
• Tzu-Yu Hua,
• Yu-Yu Chu,
• Tsai-Yuan Chiu,
• Jung-Yu Liu,
• Chun-I Tu,
• Kai-Cheng Hsu,
• Ya-Ting Kao,
• Jhih-Wei Chu,
• Yu-Yuan Hsiao

Affiliations

Kuan-Wei Huang

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Jing-Wen Chen

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Tzu-Yu Hua

Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Yu-Yu Chu

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Tsai-Yuan Chiu

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Jung-Yu Liu

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Chun-I Tu

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Kai-Cheng Hsu

Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

Ya-Ting Kao

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Jhih-Wei Chu

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Yu-Yuan Hsiao

Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan