Romanian Journal of Neurology (Sep 2020)

Effectiveness of intravenous ibuprofen compared to intravenous ketorolac for improving the sleep quality patients of acute non-specific musculoskeletal pains

  • Izaldy Taslim Pinzon,
  • Febrina Eva Susanto

DOI
https://doi.org/10.37897/RJN.2020.3.8
Journal volume & issue
Vol. 19, no. 3
pp. 186 – 192

Abstract

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Background. Acute musculoskeletal pain is a common health problem. Patients with acute musculoskeletal pain, will experience disturbance sleep. Pain reduction will improve sleep quality. Studies about intravenous Ibuprofen for treating musculoskeletal pain is very limited in Indonesia. Objective. To compare the sleep quality in patients with non-specific acute musculoskeletal pain between intravenous Ibuprofen versus intravenous Ketorolac Method. This study uses a quasi-experimental research method with non equivalent, active comparation, and open label study. There were 60 subjects participated in the study and they were divided into 2 groups who received Ibuprofen or Ketorolac, then compared with respect to effectiveness (pain reduction 8, 16, 24 and 48 hours after injection and sleep quality after 48 hours), the possibility of adverse events and rescue medication. Data were analyzed bivariately with Mann Whitney test. Results. Mean age of subjects 57.00 ± 15.125 years. A total of 60 subjects were divided into 2 groups. Both groups are equal in terms of baseline characteristics. The pain reduction in the Ibuprofen group was significantly greater than the group that received Ketorolac (p = 0.006, p <0.001, p = 0.006). Sleep quality in the Ibuprofen group was significantly better compared with Ketorolac group (p < 0.001). A total of 35 (58.3%) subjects experienced a decrease in pain scale and improvement in sleep quality (p = 0.022). There was no significant difference in the use of rescue medication between the two groups (p = 0.104). There was a significant difference seen in adverse events (gastrointestinal) between the two groups (p = 0.004).conclusions. Intravenous Ibuprofen is more effective compared with intravenous Ketorolac for improving sleep quality patients with acute non-specific musculoskeletal pain.

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