Nature Communications (Feb 2020)

A comparative genomics methodology reveals a widespread family of membrane-disrupting T6SS effectors

  • Chaya M. Fridman,
  • Kinga Keppel,
  • Motti Gerlic,
  • Eran Bosis,
  • Dor Salomon

DOI
https://doi.org/10.1038/s41467-020-14951-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Gram-negative bacteria deliver effectors via the type VI secretion system (T6SS) to outcompete their rivals. Here, Fridman et al. present an approach to identify T6SS effectors encoded in bacterial genomes without prior knowledge of their domain content or genetic neighbourhood, and identify a new family of membrane-disrupting effectors.