Nature Communications (Jul 2019)

Target specific functions of EPL interneurons in olfactory circuits

  • Gary Liu,
  • Emmanouil Froudarakis,
  • Jay M. Patel,
  • Mikhail Y. Kochukov,
  • Brandon Pekarek,
  • Patrick J. Hunt,
  • Mayuri Patel,
  • Kevin Ung,
  • Chia-Hsuan Fu,
  • Juyeong Jo,
  • Hyun-Kyoung Lee,
  • Andreas S. Tolias,
  • Benjamin R. Arenkiel

DOI
https://doi.org/10.1038/s41467-019-11354-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The precise cell-type specific role of inhibitory interneurons in regulating sensory responses in the olfactory bulb is not known. Here, the authors report that removing GABAergic inhibition from one layer differentially affects response dynamics of the two main output cell types and changes odor mixture processing.