Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan

Tatsuya Tada; Kohei Uechi; Isamu Nakasone; Masashi Nakamatsu; Kazuhito Satou; Takashi Hirano; Teruo Kirikae; Jiro Fujita

International Journal of Infectious Diseases (Oct 2018)

Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan

Tatsuya Tada,
Kohei Uechi,
Isamu Nakasone,
Masashi Nakamatsu,
Kazuhito Satou,
Takashi Hirano,
Teruo Kirikae,
Jiro Fujita

Affiliations

Tatsuya Tada: Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan
Kohei Uechi: Division of Clinical Laboratory and Blood Transfusion, University Hospital of the Ryukyus, Okinawa, Japan; Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Isamu Nakasone: Control and Prevention of Infectious Disease, University Hospital of the Ryukyus, Okinawa, Japan
Masashi Nakamatsu: Department of Infectious Diseases, Faculty of the Ryukyus, Okinawa, Japan
Kazuhito Satou: Okinawa Institute of Advanced Science, Okinawa, Japan; Department of Genome Medicine, Research Institute, National Center for Children Health and Development, Tokyo, Japan
Takashi Hirano: Okinawa Institute of Advanced Science, Okinawa, Japan
Teruo Kirikae: Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan; Corresponding author at: Department of Microbiology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Jiro Fujita: Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan

Journal volume & issue: Vol. 75
pp. 98 – 100

Abstract

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The mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to colistin by transferring phosphoethanolamine to lipid A. A 33-kb IncX4 plasmid harboring mcr-1 was detected in a Klebsiella pneumoniae isolate and two Escherichia coli isolates, and a 66-kb IncI2 plasmid was detected in three E. coli isolates in hospitals in Okinawa, Japan. Keywords: Colistin resistance, MCR-1 producing Klebsiella pneumoniae, IncX4 plasmid harboring mcr-1

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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