Targeting Ion Channel TRPM4

Barbara Preti; Jean-Sébastien Rougier; Irida Papapostolou; Florian Bochen; Christian E. Gerber; Hugues Abriel; Martin Lochner; Christine Peinelt

doi:10.2533/chimia.2022.1039

CHIMIA (Dec 2022)

Affiliations

Barbara Preti: Institute if Biochemistry and Molecular Medicine, University of Bern
Jean-Sébastien Rougier: Institute of Biochemistry and Molecular Medicine, University of Bern
Irida Papapostolou: Institute of Biochemistry and Molecular Medicine, University of Bern
Florian Bochen: Institute of Biochemistry and Molecular Medicine, University of Bern
Christian E. Gerber: Institute of Biochemistry and Molecular Medicine, University of Bern
Hugues Abriel: Institute of Biochemistry and Molecular Medicine, University of Bern
Martin Lochner: Institute of Biochemistry and Molecular Medicine, University of Bern
Christine Peinelt: Institute of Biochemistry and Molecular Medicine, University of Bern

DOI: https://doi.org/10.2533/chimia.2022.1039
Journal volume & issue: Vol. 76, no. 12

Abstract

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The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecules that block TRPM4 in the low µM range. Furthermore, we investigated the pathophysiology of TRPM4 in cardiac conditions, immune diseases and cancer using these novel inhibitors, molecular biology techniques and functional assays.

Published in CHIMIA

ISSN: 0009-4293 (Print); 2673-2424 (Online)
Publisher: Swiss Chemical Society
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://chimia.ch

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