Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

Sunil V. Sharma; Xiaoxue Tong; Cristina Pubill-Ulldemolins; Christopher Cartmell; Emma J. A. Bogosyan; Emma J. Rackham; Enrico Marelli; Refaat B. Hamed; Rebecca J. M. Goss

doi:10.1038/s41467-017-00194-3

Nature Communications (Aug 2017)

Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

Sunil V. Sharma,
Xiaoxue Tong,
Cristina Pubill-Ulldemolins,
Christopher Cartmell,
Emma J. A. Bogosyan,
Emma J. Rackham,
Enrico Marelli,
Refaat B. Hamed,
Rebecca J. M. Goss

Affiliations

Sunil V. Sharma: School of Chemistry, University of St Andrews
Xiaoxue Tong: School of Chemistry, University of St Andrews
Cristina Pubill-Ulldemolins: School of Chemistry, University of St Andrews
Christopher Cartmell: School of Chemistry, University of St Andrews
Emma J. A. Bogosyan: School of Chemistry, University of St Andrews
Emma J. Rackham: School of Chemistry, University of East
Enrico Marelli: School of Chemistry, University of St Andrews
Refaat B. Hamed: School of Chemistry, University of St Andrews
Rebecca J. M. Goss: School of Chemistry, University of St Andrews

DOI: https://doi.org/10.1038/s41467-017-00194-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

Read online

Coupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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