An Efficient Disinfectant, Composite Material {SLS@[Zn<sub>3</sub>(CitH)<sub>2</sub>]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens
V.A. Karetsi,
C.N. Banti,
N. Kourkoumelis,
C. Papachristodoulou,
C.D. Stalikas,
C.P. Raptopoulou,
V. Psycharis,
P. Zoumpoulakis,
T. Mavromoustakos,
I. Sainis,
S.K. Hadjikakou
Affiliations
V.A. Karetsi
Inorganic Chemistry laboratory, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
C.N. Banti
Inorganic Chemistry laboratory, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
N. Kourkoumelis
Medical Physics Laboratory, Medical School, University of Ioannina, 45110 Ioannina, Greece
C. Papachristodoulou
Department of Physics, University of Ioannina, 45110 Ioannina, Greece
C.D. Stalikas
Laboratory of Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
C.P. Raptopoulou
Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”, 15341 Athens, Greece
V. Psycharis
Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”, 15341 Athens, Greece
P. Zoumpoulakis
Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece
T. Mavromoustakos
Organic Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, 15571 Athens, Greece
I. Sainis
Cancer Biobank Center, University of Ioannina, 45110 Ioannina, Greece
S.K. Hadjikakou
Inorganic Chemistry laboratory, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
The [Zn3(CitH)2] (1) (CitH4= citric acid), was dispersed in sodium lauryl sulphate (SLS) to form the micelle of SLS@[Zn3(CitH)2] (2). This material 2 was incorporated in hydrogel made by hydroxyethyl-methacrylate (HEMA), an ingredient of contact lenses, toward the formation of pHEMA@(SLS@[Zn3(CitH)2]) (3). Samples of 1 and 2 were characterized by UV-Vis, 1H-NMR, FT-IR, FT-Raman, single crystal X-ray crystallography, X-ray fluorescence analysis, atomic absorption and TG/DTA/DSC. The antibacterial activity of 1−3 as well as of SLS against Gram-positive (Staphylococcus epidermidis (St. epidermidis) and Staphylococcus aureus (St. aureus)) and Gram-negative (Pseudomonas aeruginosa (PAO1), and Escherichia coli (E. coli)) bacteria was evaluated by the means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibitory zone (IZ). 2 showed 10 to 20-fold higher activity than 1 against the bacteria tested. Moreover the 3 decreases the abundance of Gram-positive microbes up to 30% (St. aureus) and up to 20% (PAO1) the Gram-negative ones. The noteworthy antimicrobial activity of the obtained composite 3 suggests an effective antimicrobial additive for infection-free contact lenses.
