Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation

Fuminori Namino MT; Munekazu Yamakuchi MD, PhD; Yasuhisa Iriki MD; Hideki Okui MD; Hitoshi Ichiki MD; Ryuichi Maenosono PhD; Naoya Oketani MD, PhD; Izumi Masamoto PhD; Masaaki Miyata MD, PhD; Masahisa Horiuchi MD, PhD; Teruto Hashiguchi MD, PhD; Mitsuru Ohishi MD, PhD; Ikuro Maruyama MD, PhD

doi:10.1177/1076029619851570

Clinical and Applied Thrombosis/Hemostasis (May 2019)

Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation

Fuminori Namino MT,
Munekazu Yamakuchi MD, PhD,
Yasuhisa Iriki MD,
Hideki Okui MD,
Hitoshi Ichiki MD,
Ryuichi Maenosono PhD,
Naoya Oketani MD, PhD,
Izumi Masamoto PhD,
Masaaki Miyata MD, PhD,
Masahisa Horiuchi MD, PhD,
Teruto Hashiguchi MD, PhD,
Mitsuru Ohishi MD, PhD,
Ikuro Maruyama MD, PhD

Affiliations

Fuminori Namino MT: Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Munekazu Yamakuchi MD, PhD: Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Yasuhisa Iriki MD: Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Hideki Okui MD: Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Hitoshi Ichiki MD: Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Ryuichi Maenosono PhD: Clinical Laboratory Unit, Kagoshima University Hospital, Kagoshima, Japan
Naoya Oketani MD, PhD: Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Izumi Masamoto PhD: Clinical Laboratory Unit, Kagoshima University Hospital, Kagoshima, Japan
Masaaki Miyata MD, PhD: Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Masahisa Horiuchi MD, PhD: Department of Hygiene and Health Promotion Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Teruto Hashiguchi MD, PhD: Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Mitsuru Ohishi MD, PhD: Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Ikuro Maruyama MD, PhD: Department of Systems Biology in Thromboregulation, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

DOI: https://doi.org/10.1177/1076029619851570
Journal volume & issue: Vol. 25

Abstract

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Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation.

Published in Clinical and Applied Thrombosis/Hemostasis

ISSN: 1076-0296 (Print); 1938-2723 (Online)
Publisher: SAGE Publishing
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://journals.sagepub.com/home/cat

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