Effect of different concentrations of sodium hyaluronate on the ocular surface change of dry eye in New Zealand rabbits

Shuang-Yong Wang; Ying Tian; Yan Cheng; Hai-Feng Zhu; Jie Wu

doi:10.3980/j.issn.1672-5123.2015.10.07

Guoji Yanke Zazhi (Oct 2015)

Effect of different concentrations of sodium hyaluronate on the ocular surface change of dry eye in New Zealand rabbits

Shuang-Yong Wang,
Ying Tian,
Yan Cheng,
Hai-Feng Zhu,
Jie Wu

Affiliations

Shuang-Yong Wang: Department of Ophthalmology, Xi'an No.1 Hospital, Xi'an 710002, Shaanxi Province, China; Shaanxi Ophthalmological Institute, Shaanxi Provincial Key Laboratory of Ophthalmology, Xi'an 710002, Shaanxi Province, China
Ying Tian: Department of Ophthalmology, Xi'an No.1 Hospital, Xi'an 710002, Shaanxi Province, China
Yan Cheng: Department of Ophthalmology, Xi'an No.1 Hospital, Xi'an 710002, Shaanxi Province, China; Shaanxi Ophthalmological Institute, Shaanxi Provincial Key Laboratory of Ophthalmology, Xi'an 710002, Shaanxi Province, China
Hai-Feng Zhu: Department of Ophthalmology, Xi'an No.1 Hospital, Xi'an 710002, Shaanxi Province, China; Shaanxi Ophthalmological Institute, Shaanxi Provincial Key Laboratory of Ophthalmology, Xi'an 710002, Shaanxi Province, China
Jie Wu: Department of Ophthalmology, Xi'an No.1 Hospital, Xi'an 710002, Shaanxi Province, China; Shaanxi Ophthalmological Institute, Shaanxi Provincial Key Laboratory of Ophthalmology, Xi'an 710002, Shaanxi Province, China

DOI: https://doi.org/10.3980/j.issn.1672-5123.2015.10.07
Journal volume & issue: Vol. 15, no. 10
pp. 1705 – 1708

Abstract

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AIM:To observe the effect of different concentrations of sodium hyaluronate on ocular surface change of dry eye. METHODS: New Zealand rabbits with dry eye was prepared and treated with 0.1% and 0.3% sodium hyaluronate drops fluid respectively, which were regarded as low concentration treatment group(group B)and high concentration treatment group(group C)respectively. However, the rabbits treated with saline were regarded as control group(group A). And then, corneal fluorescein staining, Schirmer test, conjunctival goblet cells, mucin expression and histological changes were observed.RESULTS: On D7 and D14 after treatment, corneal fluorescein staining scores were lower in group B and group C than that in group A(PP PCONCLUSION: The sodium hyaluronate can improve ocular surface damage of dry eye in New Zealand rabbits. The high concentration of sodium hyaluronate has better effect than low concentration.

Published in Guoji Yanke Zazhi

ISSN: 1672-5123 (Print)
Publisher: Press of International Journal of Ophthalmology (IJO PRESS)
Country of publisher: China
LCC subjects: Medicine: Ophthalmology
Website: http://ies.ijo.cn/

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