Effect of Mannose-Binding Lectin Gene Polymorphism on Infection in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

Abstract

Introduction:The aim of this study was to investigate the association of mannose-binding lectin (MBL), which is involved in the classical complement pathway in innate immunity, with infections in the autologous hematopoietic stem cell transplantation (AHSCT) process and the frequency of MBL gene polymorphism.Methods:Single gene nucleotide polymorphisms of codons 52 and 54 in exon 1 of the MBL-2 gene were investigated in 30 patients who had received AHSCT with a diagnosis of multiple myeloma in the Adult Bone Marrow Transplant Unit between January 2020 and December 2020. Demographic characteristics, engraftment times, and infectious processes of the patients were recorded.Results:Neutropenic fever developed at least once in 28 (93.3%) patients during AHSCT. During hospitalization pneumonia developed in 6 (20%), urinary tract infection in 4 (13.3%), and catheter infection in 4 (13.3%) patients. MBL gene polymorphism at codon 54 was found in 4 (13.3%) of the patients included in the study. Among the 4 patients with MBL gene polymorphism, 2 had pneumonia and 2 had urinary tract infection (p=0.16 and p=0.07, respectively). There was no difference between the patients with MBL gene polymorphism and those without MBL gene polymorphism in terms of age, gender, and infection type (p>0.05).Conclusion:Bacterial infection was observed in all patients with MBL gene polymorphism during AHSCT. This may be related to the increased susceptibility to infection caused by MBL gene polymorphism. However, in this study no relationship was found between MBL gene polymorphism and infection frequency and type in AHSCT.

Keywords

• mannose-binding lectin
• autologous
• transplantation