Peptide density targets and impedes triple negative breast cancer metastasis

Daxing Liu; Peng Guo; Craig McCarthy; Biran Wang; Yu Tao; Debra Auguste

doi:10.1038/s41467-018-05035-5

Nature Communications (Jul 2018)

Peptide density targets and impedes triple negative breast cancer metastasis

Daxing Liu,
Peng Guo,
Craig McCarthy,
Biran Wang,
Yu Tao,
Debra Auguste

Affiliations

Daxing Liu: Department of Biomedical Engineering, The City College of New York. New York
Peng Guo: Department of Biomedical Engineering, The City College of New York. New York
Craig McCarthy: Department of Biomedical Engineering, The City College of New York. New York
Biran Wang: Department of Biomedical Engineering, The City College of New York. New York
Yu Tao: Department of Biomedical Engineering, The City College of New York. New York
Debra Auguste: Department of Biomedical Engineering, The City College of New York. New York

DOI: https://doi.org/10.1038/s41467-018-05035-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The C-X-C chemokine receptor type 4 (CXCR4) pathway is a key regulator of cancer metastasis. Here, the authors present a method to block CXCR4 and thereby inhibit breast cancer metastasis by developing a liposome that presents CXCR4-binding peptides in a multivalent fashion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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