Nature Communications (Jan 2018)

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

  • Milica Tosic,
  • Anita Allen,
  • Dominica Willmann,
  • Christoph Lepper,
  • Johnny Kim,
  • Delphine Duteil,
  • Roland Schüle

DOI
https://doi.org/10.1038/s41467-017-02740-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice.