Prognostic value of CD4+ T lymphopenia in non-small cell lung Cancer

Guillaume Eberst; Dewi Vernerey; Caroline Laheurte; Aurélia Meurisse; Vincent Kaulek; Laurie Cuche; Pascale Jacoulet; Hamadi Almotlak; Jean Lahourcade; Marie Gainet-Brun; Elizabeth Fabre; Françoise Le Pimpec-Barthes; Olivier Adotevi; Virginie Westeel

doi:10.1186/s12885-022-09628-8

BMC Cancer (May 2022)

Prognostic value of CD4+ T lymphopenia in non-small cell lung Cancer

Guillaume Eberst,
Dewi Vernerey,
Caroline Laheurte,
Aurélia Meurisse,
Vincent Kaulek,
Laurie Cuche,
Pascale Jacoulet,
Hamadi Almotlak,
Jean Lahourcade,
Marie Gainet-Brun,
Elizabeth Fabre,
Françoise Le Pimpec-Barthes,
Olivier Adotevi,
Virginie Westeel

Affiliations

Guillaume Eberst: Chest Disease Department, University Hospital
Dewi Vernerey: Methodology and Quality of Life in Oncology Unit, University Hospital
Caroline Laheurte: Université de Bourgogne Franche-Comté
Aurélia Meurisse: Methodology and Quality of Life in Oncology Unit, University Hospital
Vincent Kaulek: Chest Disease Department, University Hospital
Laurie Cuche: Chest Disease Department, University Hospital
Pascale Jacoulet: Chest Disease Department, University Hospital
Hamadi Almotlak: Department of Medical Oncology, University Hospital
Jean Lahourcade: Chest Disease Department, University Hospital
Marie Gainet-Brun: Chest Disease Department, University Hospital
Elizabeth Fabre: Department of Medical Oncology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou
Françoise Le Pimpec-Barthes: Department of Thoracic surgery, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou
Olivier Adotevi: Université de Bourgogne Franche-Comté
Virginie Westeel: Chest Disease Department, University Hospital

DOI: https://doi.org/10.1186/s12885-022-09628-8
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 11

Abstract

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Highlights This study investigates the unknown prognostic influence of peripheral blood CD4+ T lymphopenia in non-small cell lung cancer (NSCLC) with long-term follow-up CD4+ but not CD8 + T lymphopenia was associated with poor survival in patients with localized NSCLC The CD4+ T lymphopenia appears to be an independent prognostic factor for poor overall survival in local/loco-regional NSCLC. CD4+ T lymphocyte count ≤500/μL in peripheral blood is associated with a high risk of death in NSCLC

Published in BMC Cancer

ISSN: 1471-2407 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://bmccancer.biomedcentral.com

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Abstract

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