Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction

Tianfei Fan; Yangfeng Hou; Weipeng Ge; Tianhui Fan; Xiaohang Feng; Wenjun Guo; Xiaomin Song; Ran Gao; Jing Wang

doi:10.1038/s42003-022-03029-0

Communications Biology (Jan 2022)

Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction

Tianfei Fan,
Yangfeng Hou,
Weipeng Ge,
Tianhui Fan,
Xiaohang Feng,
Wenjun Guo,
Xiaomin Song,
Ran Gao,
Jing Wang

Affiliations

Tianfei Fan: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College
Yangfeng Hou: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College
Weipeng Ge: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College
Tianhui Fan: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College
Xiaohang Feng: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College
Wenjun Guo: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College
Xiaomin Song: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College
Ran Gao: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College
Jing Wang: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College

DOI: https://doi.org/10.1038/s42003-022-03029-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

Read online

Fan, Hou et al. investigate the role of phosphodiesterase (PDE) 4 and the PDE4-cAMP-PKA pathway on hypertension, reporting that PDE4D is upregulated in hypertension induced by angiotensin II. The authors also show that Pde4d knockout in mouse SMCs attenuates Ang II-induced hypertension and implicate AMPK signalling and MYPT1-MLC phosphorylation in Ang II-induced SMC contraction.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal