Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption

Scott A. Williams; Fung T. Lay; Guneet K. Bindra; Suresh Banjara; Ivan K. H. Poon; Thanh Kha Phan; Marc Kvansakul; Mark D. Hulett

doi:10.1038/s41467-023-36280-y

Nature Communications (Mar 2023)

Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption

Scott A. Williams,
Fung T. Lay,
Guneet K. Bindra,
Suresh Banjara,
Ivan K. H. Poon,
Thanh Kha Phan,
Marc Kvansakul,
Mark D. Hulett

Affiliations

Scott A. Williams: Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University
Fung T. Lay: Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University
Guneet K. Bindra: Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University
Suresh Banjara: Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University
Ivan K. H. Poon: Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University
Thanh Kha Phan: Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University
Marc Kvansakul: Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University
Mark D. Hulett: Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University

DOI: https://doi.org/10.1038/s41467-023-36280-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 11

Abstract

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Defensins are a class of host defence peptides that contribute to the immune system of eukaryotes. Here, the authors report the structure of saltwater crocodile defensin CpoBD13 and the mechanism of pH-dependent antifungal activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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