Molbank (May 2021)

Ammonium Salts of 5-(3-Chromenyl)-5<i>H</i>-chromeno[2,3-<i>b</i>]pyridines

  • Yuliya E. Ryzhkova,
  • Artem N. Fakhrutdinov,
  • Michail N. Elinson

Journal volume & issue
Vol. 2021, no. M1219
p. M1219


Read online

The ammonium salts of many drugs have significantly improved the solubility and, accordingly, the bioavailability of medicinal substances in the human body. 5-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-5H-chromeno[2,3-b]pyridines are potential NPY1R ligands, which are attractive for antiobesity treatment. Ammonium salts of 5H-chromeno[2,3-b]pyridines were previously unknown. In this communication, it was found that the four-component reaction of salicylaldehyde, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, 4-Hydroxy-2H-chromen-2-one and amines results in the formation of ammonium salts of 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines. The structure of these previously unknown compounds was confirmed by means of 1H, 13C NMR and IR spectroscopy, mass spectrometry and elemental analysis.