Nature Communications (Jul 2016)

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

  • Anne-Elisabeth Petit,
  • Nathalie Demotte,
  • Benoît Scheid,
  • Claude Wildmann,
  • René Bigirimana,
  • Monica Gordon-Alonso,
  • Javier Carrasco,
  • Salvatore Valitutti,
  • Danièle Godelaine,
  • Pierre van der Bruggen

DOI
https://doi.org/10.1038/ncomms12242
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and target cell killing.