Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys

Abstract

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Chronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8%–16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multiple signaling pathways, including WNT/β-catenin.Aberrant activation of WNT/β-catenin is implicated in renal fibrosis. The roles of renal macrophages and fibroblasts are pivotal in fibrosis progression and prognosis.

Keywords

• cross-talk
• kidney fibrosis
• wnt/β-catenin signaling
• macrophage
• fibroblast