Hodgkin’s Lymphoma Concurrent with Amyloidosis: A Rare Case Report

Abstract

Hodgkin’s lymphoma is a neoplasm of lymphoid tissue. Histopathological examination with evidence of Reed-Sternberg cells in the background of inflammatory cells combined with immunohistochemistry for specific markers is confirmatory in order to diagnose Hodgkin’s lymphoma. Amyloidosis is a protein misfolding disorder characterised by amyloid deposition in various organs. Diagnosis involves histochemical examination using Congo red, which is a special stain. It is a rare phenomenon to witness both pathologies concurrently in a single patient. It is very challenging as it involves intricate diagnostic, therapeutic, as well as prognostic implications for the patient. Here, a case of a 45-year-old female who presented clinically with a painful swelling on the right-side of the neck. Thorough investigations confirmed the diagnosis of Hodgkin’s lymphoma coupled with amyloidosis. The patient was given chemotherapy for Hodgkin’s lymphoma but was simultaneously closely monitored for any complications or side-effects related to amyloidosis. Additionally, a novel therapy approach was structured for treating amyloidosis. Thus, it highlights the importance of a multidisciplinary approach for the diagnosis, management, and prognosis for such patients. To gain a deeper understanding of this specific relationship and ultimately improve the prognosis of the patients, additional research is extremely crucial.

Keywords

• amyloid fibril
• congo red
• reed sternberg cell