Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation

Jiajia Wang; Hanqing He; Binbin Chen; Guixing Jiang; Liping Cao; Haiping Jiang; Guofei Zhang; Jianxiang Chen; Jun Huang; Bing Yang; Chun Zhou; Ting Liu

doi:10.1038/s41467-020-14564-x

Nature Communications (Feb 2020)

Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation

Jiajia Wang,
Hanqing He,
Binbin Chen,
Guixing Jiang,
Liping Cao,
Haiping Jiang,
Guofei Zhang,
Jianxiang Chen,
Jun Huang,
Bing Yang,
Chun Zhou,
Ting Liu

Affiliations

Jiajia Wang: Department of Cell Biology, and Department of General Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hanqing He: The MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Binbin Chen: Department of Cell Biology, and Department of General Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Guixing Jiang: Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Liping Cao: Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Haiping Jiang: Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine
Guofei Zhang: Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine
Jianxiang Chen: Department of Radiotherapy, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital
Jun Huang: The MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Bing Yang: The MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Chun Zhou: Department of Cell Biology, and Department of General Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Ting Liu: Department of Cell Biology, and Department of General Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-14564-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The XPF-ERCC1 heterodimer is an endonuclease involved in nucleotide excision (NER) and interstrand crosslink (ICL) repair in mammalian cells. Here, the authors provide insights into its regulation by revealing that TIP60 regulates XPF-ERCC1 complex assembly and activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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