Nature Communications (Mar 2021)

Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation

  • Laleh Abbassi,
  • Stephany El-Hayek,
  • Karen Freire Carvalho,
  • Wusu Wang,
  • Qin Yang,
  • Sofia Granados-Aparici,
  • Rafael Mondadori,
  • Vilceu Bordignon,
  • Hugh J. Clarke

DOI
https://doi.org/10.1038/s41467-021-21644-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Uncoupling of mature oocytes from somatic granulosa cells is required for their fertilization. Here the authors show that activation of EGFR signalling in granulosa cells during ovulation triggers ERK-dependent loss of filopodia oocyte adhesion, and Arp2/3 mediated retraction of granulosa cell filopodia.