PLoS ONE (Jan 2013)

Prognostic value of radiological response to chemotherapy in patients with osteosarcoma.

  • Shinji Miwa,
  • Akihiko Takeuchi,
  • Toshiharu Shirai,
  • Junichi Taki,
  • Norio Yamamoto,
  • Hideji Nishida,
  • Katsuhiro Hayashi,
  • Yoshikazu Tanzawa,
  • Hiroaki Kimura,
  • Kentaro Igarashi,
  • Akishi Ooi,
  • Hiroyuki Tsuchiya

DOI
https://doi.org/10.1371/journal.pone.0070015
Journal volume & issue
Vol. 8, no. 7
p. e70015

Abstract

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BackgroundChemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EFS) was evaluated.MethodEighty-two patients with high-grade osteosarcoma were included in this study, and we evaluated the following factors for prognostic significance: age (≥40 years), gender (male), tumor location (truncal site), metastatic disease, histological response to chemotherapy, radiological response to chemotherapy assessed using X-ray, angiography, CT, MRI, (201)Tl scintigraphy, and (99m)Tc-MIBI scintigraphy ((99m)Tc-MIBI), and combined radiological score (CRS).ResultsUnivariate analyses revealed that metastatic disease, histological response, (99m)Tc-MIBI, and CRS were significantly correlated with OS. Multivariate analyses showed that metastatic disease (OS: HR 35.9, PConclusionThe chemotherapeutic effects evaluated by (99m)Tc-MIBI and CRS could be considered as prognostic factors in osteosarcoma.