Drug Design, Development and Therapy (Dec 2023)
Caged Polyprenylated Xanthones in Garcinia hanburyi and the Biological Activities of Them
Abstract
Ruixi He, Buyun Jia, Daiyin Peng, Weidong Chen School of Pharmacy, Anhui University of Chinese Medicine, Hefei, People’s Republic of ChinaCorrespondence: Ruixi He, School of Pharmacy, Anhui University of Chinese Medicine, No. 350 Longzihu Road, Xinzhan District, Hefei, 230012, People’s Republic of China, Tel +8613637080511, Fax +8655168129099, Email [email protected]: The previous phytochemical analyses of Garcinia hanburyi revealed that the main structural characteristic associated with its biological activity is the caged polyprenylated xanthones with a unique 4-oxatricyclo [4.3.1.03,7] dec-2-one scaffold, which contains a highly substituted tetrahydrofuran ring with three quaternary carbons. Based on the progress in research of the chemical constituents, pharmacological effects and modification methods of the caged polyprenylated xanthones, this paper presents a preliminary predictive analysis of their drug-like properties based on the absorption, distribution, metabolism, excretion and toxicity (ADME/T) properties. It was found out that these compounds have very similar pharmacokinetic properties because they possess the same caged xanthone structure, the 9,10-double bond in a,b-unsaturated ketones are critical for the antitumor activity. The author believes that there is an urgent need to seek new breakthroughs in the study of these caged polyprenylated xanthones. Thus, the research on the route of administration, therapeutic effect, structural modification and development of such active ingredients is of great interest. It is hoped that this paper will provide ideas for researchers to develop and utilize the active ingredients derived from natural products. Keywords: caged polyprenylated xanthones, pharmacological effects, antitumor, modification, ADME/T properties
