Nature Communications (Feb 2023)
Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells
- Ewan A. Ross,
- Lesley-Anne Turner,
- Hannah Donnelly,
- Anwer Saeed,
- Monica P. Tsimbouri,
- Karl V. Burgess,
- Gavin Blackburn,
- Vineetha Jayawarna,
- Yinbo Xiao,
- Mariana A. G. Oliva,
- Jennifer Willis,
- Jaspreet Bansal,
- Paul Reynolds,
- Julia A. Wells,
- Joanne Mountford,
- Massimo Vassalli,
- Nikolaj Gadegaard,
- Richard O. C. Oreffo,
- Manuel Salmeron-Sanchez,
- Matthew J. Dalby
Affiliations
- Ewan A. Ross
- Centre for the Cellular Microenvironment, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Lesley-Anne Turner
- Centre for the Cellular Microenvironment, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Hannah Donnelly
- Centre for the Cellular Microenvironment, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Anwer Saeed
- Division of Biomedical Engineering, James Watt School of Engineering, University of Glasgow
- Monica P. Tsimbouri
- Centre for the Cellular Microenvironment, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Karl V. Burgess
- Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, Bearsden
- Gavin Blackburn
- Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, Bearsden
- Vineetha Jayawarna
- Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Yinbo Xiao
- Centre for the Cellular Microenvironment, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Mariana A. G. Oliva
- Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Jennifer Willis
- School of Biosciences, College of Health and Life Sciences, Aston University
- Jaspreet Bansal
- School of Biosciences, College of Health and Life Sciences, Aston University
- Paul Reynolds
- Division of Biomedical Engineering, James Watt School of Engineering, University of Glasgow
- Julia A. Wells
- Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton
- Joanne Mountford
- Scottish National Blood Transfusion Service, Advanced Therapeutics, Jack Copland Centre
- Massimo Vassalli
- Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Nikolaj Gadegaard
- Division of Biomedical Engineering, James Watt School of Engineering, University of Glasgow
- Richard O. C. Oreffo
- Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton
- Manuel Salmeron-Sanchez
- Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- Matthew J. Dalby
- Centre for the Cellular Microenvironment, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, Mazumdar-Shaw Advanced Research Centre, University of Glasgow
- DOI
- https://doi.org/10.1038/s41467-023-36293-7
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Mesenchymal Stromal Cells are hard to expand whilst retaining immunomodulatory properties due to spontaneous differentiation and ageing in culture. Here, the authors describe a mechanotransductive link between metabolism and functional activity and identify bioactive metabolites to expand functional MSCs at cell therapy scale.
