International Journal of Nanomedicine (Jul 2022)
How Microalgae is Effective in Oxygen Deficiency Aggravated Diseases? A Comprehensive Review of Literature
Abstract
Hengqing Cui,1,* Yidan Su,1,* Wei Wei,2,* Fei Xu,3 Jie Gao,2 Wenjun Zhang2 1Department of Burns and Plastic Surgery, Shanghai Changzheng Hospital, Shanghai, 200003, People’s Republic of China; 2Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China; 3Department of Plastic Surgery, Naval Medical Center, Naval Medical University, Shanghai, 200052, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenjun Zhang, Department of Burns and Plastic Surgery, Shanghai Changzheng Hospital, Shanghai, 200001, People’s Republic of China, Tel +86 21 81885775, Fax +86 21 81886000, Email [email protected] Jie Gao, Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China, Tel +86 21 81871290, Fax +86 21 81871290, Email [email protected]: Hypoxia can aggravate the conditions of many oxygen-deficiency-aggravated diseases (ODAD), such as cancer, ischemic heart disease, and chronic wounds. Photosynthetic microalgae can alleviate the hepatotoxicity of the local microenvironment by producing oxygen. In addition, microalgae extracts have antitumor, anti-inflammatory, antibacterial, and antioxidant effects. These properties make them attractive candidates for developing methods to treat ODAD. Although researchers have exploited the advantages of microalgae and developed a variety of microalgae-based biomaterials to treat ODAD, a comprehensive review of this topic has not been presented previously. Therefore, in this review, we summarize the development and progress made in the field of developing microalgae-based biomaterials toward the treatment of ODAD. The challenges and prospects of this field are also discussed.Keywords: chronic wounds, tumors, ischemic heart disease, hypoxia, oxygen generation
