Frontiers in Psychiatry (Feb 2022)

Psychotic Symptoms as the Initial Presentation of a Long-Lasting Misdiagnosed Anti-GAD65 Autoimmune Encephalitis: An Emblematic Case and Literature Review

  • Jianjun Wang,
  • Jianjun Wang,
  • Jianjun Wang,
  • Shenglan Gong,
  • Shenglan Gong,
  • Shenglan Gong,
  • Fanxin Kong,
  • Fanxin Kong,
  • Dongbin Cai,
  • Dongbin Cai,
  • Binqing Huang,
  • Binqing Huang,
  • Haotao Zheng,
  • Haotao Zheng,
  • Songjun Lin,
  • Songjun Lin,
  • Jinfang Li,
  • Jinfang Li,
  • Tianfeng Zhang,
  • Tianfeng Zhang

DOI
https://doi.org/10.3389/fpsyt.2022.754938
Journal volume & issue
Vol. 13

Abstract

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ObjectiveTo present a long-lasting misdiagnosed case of anti-GAD65 autoimmune encephalitis (AE) and promote the early identification of reversible psychotic symptoms in AE.MethodsThe case report was generated through detailed assessment of clinical characteristics, cerebral magnetic resonance images, and laboratory results. Meanwhile, a literatures review related to the topic was conducted.ResultsPsychotic symptoms could be presented in the early stage of anti-GAD65 autoimmune encephalitis. Even though there exists a transdisciplinary gap that hinder the timely recognition of early psychiatric symptoms as components of organic disease, a few strategies could be introduced to enable the earlier recognition and appropriate treatment.ConclusionsOur report intends to raise awareness to promote the early identification of immune-mediated “symptomatic” forms of psychosis.

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