Nature Communications (Oct 2018)
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
- Alexander Teumer,
- Layal Chaker,
- Stefan Groeneweg,
- Yong Li,
- Celia Di Munno,
- Caterina Barbieri,
- Ulla T. Schultheiss,
- Michela Traglia,
- Tarunveer S. Ahluwalia,
- Masato Akiyama,
- Emil Vincent R. Appel,
- Dan E. Arking,
- Alice Arnold,
- Arne Astrup,
- Marian Beekman,
- John P. Beilby,
- Sofie Bekaert,
- Eric Boerwinkle,
- Suzanne J. Brown,
- Marc De Buyzere,
- Purdey J. Campbell,
- Graziano Ceresini,
- Charlotte Cerqueira,
- Francesco Cucca,
- Ian J. Deary,
- Joris Deelen,
- Kai-Uwe Eckardt,
- Arif B. Ekici,
- Johan G. Eriksson,
- Luigi Ferrrucci,
- Tom Fiers,
- Edoardo Fiorillo,
- Ian Ford,
- Caroline S. Fox,
- Christian Fuchsberger,
- Tessel E. Galesloot,
- Christian Gieger,
- Martin Gögele,
- Alessandro De Grandi,
- Niels Grarup,
- Karin Halina Greiser,
- Kadri Haljas,
- Torben Hansen,
- Sarah E. Harris,
- Diana van Heemst,
- Martin den Heijer,
- Andrew A. Hicks,
- Wouter den Hollander,
- Georg Homuth,
- Jennie Hui,
- M. Arfan Ikram,
- Till Ittermann,
- Richard A. Jensen,
- Jiaojiao Jing,
- J. Wouter Jukema,
- Eero Kajantie,
- Yoichiro Kamatani,
- Elisa Kasbohm,
- Jean-Marc Kaufman,
- Lambertus A. Kiemeney,
- Margreet Kloppenburg,
- Florian Kronenberg,
- Michiaki Kubo,
- Jari Lahti,
- Bruno Lapauw,
- Shuo Li,
- David C. M. Liewald,
- Lifelines Cohort Study,
- Ee Mun Lim,
- Allan Linneberg,
- Michela Marina,
- Deborah Mascalzoni,
- Koichi Matsuda,
- Daniel Medenwald,
- Christa Meisinger,
- Ingrid Meulenbelt,
- Tim De Meyer,
- Henriette E. Meyer zu Schwabedissen,
- Rafael Mikolajczyk,
- Matthijs Moed,
- Romana T. Netea-Maier,
- Ilja M. Nolte,
- Yukinori Okada,
- Mauro Pala,
- Cristian Pattaro,
- Oluf Pedersen,
- Astrid Petersmann,
- Eleonora Porcu,
- Iris Postmus,
- Peter P. Pramstaller,
- Bruce M. Psaty,
- Yolande F. M. Ramos,
- Rajesh Rawal,
- Paul Redmond,
- J. Brent Richards,
- Ernst R. Rietzschel,
- Fernando Rivadeneira,
- Greet Roef,
- Jerome I. Rotter,
- Cinzia F. Sala,
- David Schlessinger,
- Elizabeth Selvin,
- P. Eline Slagboom,
- Nicole Soranzo,
- Thorkild I. A. Sørensen,
- Timothy D. Spector,
- John M. Starr,
- David J. Stott,
- Youri Taes,
- Daniel Taliun,
- Toshiko Tanaka,
- Betina Thuesen,
- Daniel Tiller,
- Daniela Toniolo,
- Andre G. Uitterlinden,
- W. Edward Visser,
- John P. Walsh,
- Scott G. Wilson,
- Bruce H. R. Wolffenbuttel,
- Qiong Yang,
- Hou-Feng Zheng,
- Anne Cappola,
- Robin P. Peeters,
- Silvia Naitza,
- Henry Völzke,
- Serena Sanna,
- Anna Köttgen,
- Theo J. Visser,
- Marco Medici
Affiliations
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Layal Chaker
- Erasmus MC Academic Center for Thyroid Diseases
- Stefan Groeneweg
- Erasmus MC Academic Center for Thyroid Diseases
- Yong Li
- Department of Biometry, Epidemiology and Medical Bioinformatics, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center—University of Freiburg
- Celia Di Munno
- Erasmus MC Academic Center for Thyroid Diseases
- Caterina Barbieri
- Division of Genetics and Cell Biology, San Raffaele Scientific Institute
- Ulla T. Schultheiss
- Department of Biometry, Epidemiology and Medical Bioinformatics, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center—University of Freiburg
- Michela Traglia
- Division of Genetics and Cell Biology, San Raffaele Scientific Institute
- Tarunveer S. Ahluwalia
- Steno Diabetes Center Copenhagen
- Masato Akiyama
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Emil Vincent R. Appel
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Dan E. Arking
- McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
- Alice Arnold
- Department of Biostatistics, University of Washington
- Arne Astrup
- Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen
- Marian Beekman
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- John P. Beilby
- Pathwest Laboratory Medicine WA
- Sofie Bekaert
- Bimetra, Clinical Research Center Ghent, Ghent University Hospital
- Eric Boerwinkle
- Human Genetics Center, University of Texas Health Science Center
- Suzanne J. Brown
- Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital
- Marc De Buyzere
- Department of Cardiology, Ghent University Hospital
- Purdey J. Campbell
- Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital
- Graziano Ceresini
- Department of Medicine and Surgery, University of Parma, University Hospital of Parma
- Charlotte Cerqueira
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region
- Francesco Cucca
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato
- Ian J. Deary
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Joris Deelen
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- Kai-Uwe Eckardt
- Department of Nephrology and Hypertension, University of Erlangen-Nürnberg
- Arif B. Ekici
- Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
- Johan G. Eriksson
- Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital
- Luigi Ferrrucci
- Translational Gerontology Branch, National Institute on Aging
- Tom Fiers
- Department of Clinical Chemistry, Ghent University Hospital
- Edoardo Fiorillo
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato
- Ian Ford
- Robertson Centre for Biostatistics, University of Glasgow
- Caroline S. Fox
- National Heart, Lung, and Blood Institute’s Framingham Heart Study and the Center for Population Studies
- Christian Fuchsberger
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck
- Tessel E. Galesloot
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Christian Gieger
- Helmholtz Zentrum München, Institute of Epidemiology, German Research Center for Environmental Health
- Martin Gögele
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck
- Alessandro De Grandi
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck
- Niels Grarup
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Karin Halina Greiser
- German Research Centre Division of Cancer Epidemiology
- Kadri Haljas
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki
- Torben Hansen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Sarah E. Harris
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Diana van Heemst
- Leiden University Medical Center, Geriatrics and Gerontology
- Martin den Heijer
- Vrije Universiteit Medisch Centrum
- Andrew A. Hicks
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck
- Wouter den Hollander
- Department of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center
- Georg Homuth
- Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
- Jennie Hui
- Pathwest Laboratory Medicine WA
- M. Arfan Ikram
- Department of Epidemiology, Erasmus Medical Center
- Till Ittermann
- Institute for Community Medicine, University Medicine Greifswald
- Richard A. Jensen
- Department of Medicine, Cardiovascular Health Research Unit, University of Washington
- Jiaojiao Jing
- Department of Biometry, Epidemiology and Medical Bioinformatics, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center—University of Freiburg
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Eero Kajantie
- National Institute for Health and Welfare
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Elisa Kasbohm
- Institute for Community Medicine, University Medicine Greifswald
- Jean-Marc Kaufman
- Department of Endocrinology, Ghent University Hospital
- Lambertus A. Kiemeney
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Margreet Kloppenburg
- Department of Rheumatology, Leiden University Medical Center
- Florian Kronenberg
- Department of Medical Genetics, Division of Genetic Epidemiology, Molecular and Clinical Pharmacology, Medical University of Innsbruck
- Michiaki Kubo
- Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
- Jari Lahti
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki
- Bruno Lapauw
- Department of Endocrinology, Ghent University Hospital
- Shuo Li
- Department of Biostatistics, Boston University
- David C. M. Liewald
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Lifelines Cohort Study
- Ee Mun Lim
- Pathwest Laboratory Medicine WA
- Allan Linneberg
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region
- Michela Marina
- Department of Medicine and Surgery, University of Parma, University Hospital of Parma
- Deborah Mascalzoni
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck
- Koichi Matsuda
- Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo
- Daniel Medenwald
- Institute for Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg
- Christa Meisinger
- Helmholtz Zentrum München, Institute of Epidemiology, German Research Center for Environmental Health
- Ingrid Meulenbelt
- Department of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center
- Tim De Meyer
- Department of Data Analysis and Mathematical Modelling, Ghent University
- Henriette E. Meyer zu Schwabedissen
- Department of Pharmaceutical Sciences, University of Basel
- Rafael Mikolajczyk
- Institute for Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg
- Matthijs Moed
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- Romana T. Netea-Maier
- Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center
- Ilja M. Nolte
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Yukinori Okada
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Mauro Pala
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato
- Cristian Pattaro
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck
- Oluf Pedersen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Astrid Petersmann
- Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
- Eleonora Porcu
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato
- Iris Postmus
- Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center
- Peter P. Pramstaller
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington
- Yolande F. M. Ramos
- Department of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center
- Rajesh Rawal
- Helmholtz Zentrum München, Institute of Epidemiology, German Research Center for Environmental Health
- Paul Redmond
- Department of Psychology, University of Edinburgh
- J. Brent Richards
- Lady Davis Institute, Jewish General Hospital
- Ernst R. Rietzschel
- Biobanking and Cardiovascular Epidemiology, Ghent University Hospital
- Fernando Rivadeneira
- Department of Epidemiology, Erasmus Medical Center
- Greet Roef
- Department of Endocrinology, Ghent University Hospital
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center
- Cinzia F. Sala
- Division of Genetics and Cell Biology, San Raffaele Scientific Institute
- David Schlessinger
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Elizabeth Selvin
- Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health
- P. Eline Slagboom
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- Nicole Soranzo
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton
- Thorkild I. A. Sørensen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Timothy D. Spector
- The Department of Twin Research and Genetic Epidemiology, King’s College London, St. Thomas’ Campus
- John M. Starr
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- David J. Stott
- Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow
- Youri Taes
- AZ Sint Jan Brugge
- Daniel Taliun
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck
- Toshiko Tanaka
- Translational Gerontology Branch, National Institute on Aging
- Betina Thuesen
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region
- Daniel Tiller
- Chair of Epidemiology, Ludwig-Maximilians-Universität München, at UNIKA-T Augsburg
- Daniela Toniolo
- Division of Genetics and Cell Biology, San Raffaele Scientific Institute
- Andre G. Uitterlinden
- Department of Epidemiology, Erasmus Medical Center
- W. Edward Visser
- Erasmus MC Academic Center for Thyroid Diseases
- John P. Walsh
- Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital
- Scott G. Wilson
- Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital
- Bruce H. R. Wolffenbuttel
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Qiong Yang
- Department of Biostatistics, Boston University
- Hou-Feng Zheng
- Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University and Westlake Institute for Advanced Study
- Anne Cappola
- Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine
- Robin P. Peeters
- Erasmus MC Academic Center for Thyroid Diseases
- Silvia Naitza
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato
- Henry Völzke
- Institute for Community Medicine, University Medicine Greifswald
- Serena Sanna
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato
- Anna Köttgen
- Department of Biometry, Epidemiology and Medical Bioinformatics, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center—University of Freiburg
- Theo J. Visser
- Erasmus MC Academic Center for Thyroid Diseases
- Marco Medici
- Erasmus MC Academic Center for Thyroid Diseases
- DOI
- https://doi.org/10.1038/s41467-018-06356-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.
