Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss

Lingna Guo; Lingna Guo; Wei Cao; Yuguang Niu; Shuangba He; Renjie Chai; Renjie Chai; Renjie Chai; Renjie Chai; Jianming Yang

doi:10.3389/fncel.2021.760422

Frontiers in Cellular Neuroscience (Oct 2021)

Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss

Lingna Guo,
Lingna Guo,
Wei Cao,
Yuguang Niu,
Shuangba He,
Renjie Chai,
Renjie Chai,
Renjie Chai,
Renjie Chai,
Jianming Yang

Affiliations

Lingna Guo: State Key Laboratory of Bioelectronics, School of Life Sciences and Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China
Lingna Guo: Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
Wei Cao: Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
Yuguang Niu: Department of Ambulatory Medicine, The First Medical Center of PLA General Hospital, Beijing, China
Shuangba He: Department of Otolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China
Renjie Chai: State Key Laboratory of Bioelectronics, School of Life Sciences and Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China
Renjie Chai: Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China
Renjie Chai: Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
Renjie Chai: Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, China
Jianming Yang: Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China

DOI: https://doi.org/10.3389/fncel.2021.760422
Journal volume & issue: Vol. 15

Abstract

Read online

Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of the auditory system. However, they are vulnerable to genetic defects, noise exposure, ototoxic drugs and aging, and loss or damage of HCs and SGNs results in permanent hearing loss due to their limited capacity for spontaneous regeneration in mammals. Many efforts have been made to combat hearing loss including cochlear implants, HC regeneration, gene therapy, and antioxidant drugs. Here we review the role of autophagy in sensorineural hearing loss and the potential targets related to autophagy for the treatment of hearing loss.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

About the journal

Abstract

Keywords