Fibrous hamartoma of the thigh in a neonate

Abstract

Fibrous hamartoma of infancy (FHI) is a rare, benign lesion characterized as a tumor of myofibroblastic origin that has characteristic features of triphasic histology. FHI was first described in 1956 by Reye and formally named by Enzinger in 1965 [1-2]. The lesion is defined as a hamartoma due to the histologic presentation of disorganized mesenchymal, fibrous, and adipose tissue with absence of mitotic figures; this combination of derived tissue without evidence of anaplasia is diagnostic for FHI. These lesions typically arise as a single, solitary mass, are most commonly located on the extremities, trunk, sacrum, or scrotum and are typically 0.5 to 9.0 centimeters in size [3-4]. Only roughly 200 cases have been reported in the literature [3]. The majority of cases occur in young children; 91% of cases arise within the first year of life [4]. Males are more often affected in a ratio of 2.4:1 [4]. Roughly 20% of cases have been documented as congenital (3). Treatment is surgical excision, which is often curative; local recurrence is rare and incidence decreased by obtaining negative margins (8). We present a case of congenital FHI identified at birth.

Keywords

• Fibrous hamartoma of infancy
• Infantile tumor
• Hamartoma