IgG4 as a diagnostic marker of inflammatory bowel disease (literature review)

Abstract

Inflammatory bowel disease (IBD), namely ulcerative colitis and Crohn’s disease, which are non-specific inflammation of the gastrointestinal tract, remain one of the most important problems of modern gastroenterology today. The golden standard for the diagnosis of IBD is an endoscopic and histological examination, but the detection and prospects of non-invasive biomarkers will improve the quality of diagnosis, allow developing new me­thods for predicting the severity of IBD, which in turn will improve therapy, change the quality life of patients with IBD. The studies of the role of humoral immunity in the pathogenesis of IBD have shown that IgG4 may be one of these markers. The article presents a review of modern literature sources on the value of IgG4 in the pathogenesis of IBD, the feasibility and specificity of the determination of IgG4 in blood plasma and tissue IgG4 as a criterion for differential diagnosis of IBD and the possibility of using it as a biomarker for predicting IBD. The search was performed using the database PubMed, MedLine, EMBASE, Cochrane library, Google scholar, Cyberleninka, eLibrary.

Keywords

• inflammatory bowel disease, ulcerative colitis, crohn’s disease, igg, igg4, igg4-related disease