Nature Communications (May 2020)

Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

  • Dorien A. Maas,
  • Vivian D. Eijsink,
  • Marcia Spoelder,
  • Josephus A. van Hulten,
  • Peter De Weerd,
  • Judith R. Homberg,
  • Astrid Vallès,
  • Brahim Nait-Oumesmar,
  • Gerard J. M. Martens

DOI
https://doi.org/10.1038/s41467-020-16218-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Dysfunction of GABAergic neurons in the prefrontal cortex has been reported in schizophrenia. Here, the authors use the apomorphine-susceptible rat, which displays some schizophrenia-like behaviors, and show that interneurons in the medial prefrontal cortex are hypomyelinated, which may contribute to this behavioral phenotype.