Research progress on the effects of tight junction on lung permeability

Abstract

The alveolar epithelial barrier and the pulmonary microvascular endothelial barrier will be destroyed when the lung tissue is damaged, thus affecting the permeability of the lung and causing serious pulmonary edema. Tight junctions (TJs) are protein complex with “fences and barriers” function that exists in epithelial cells and endothelial cells, and are crucial to the regulation of lung permeability. This paper mainly reviews the research progress on the effects of tight junction proteins on lung permeability, which can deepen the understanding of this problem and provides new ideas for clinical treatment.

Keywords

• tight junctions|pulmonary permeability|alveolar epithelial barrier|pulmonary endothelial barrier