Journal of Multidisciplinary Healthcare (Dec 2024)
Cerebral Microbleeds and Antiplatelet Therapy in Mongolian and Han Patients with Ischemic Cerebrovascular Disease
Abstract
Haichao Fu,1 Lihong Ge,1 Junguo Liang2 1Department of Diagnostic Imaging, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, Inner Mongolia, People’s Republic of China; 2Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, Inner Mongolia, People’s Republic of ChinaCorrespondence: Lihong Ge, Department of Diagnostic Imaging, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot City, Inner Mongolia, 010000, People’s Republic of China, Tel +86 15304719599, Email [email protected] Junguo Liang, Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot City, Inner Mongolia, 010000, People’s Republic of China, Email [email protected]: To analyze the differences in cerebral microbleeds (CMBs) and their correlation with intracerebral hemorrhage (ICH) in Mongolian and Han Chinese patients with ischemic cerebrovascular disease.Methods: A total of 160 patients with ischemic cerebrovascular disease who took aspirin or clopidogrel for over one year were retrospectively analyzed, including 80 Mongolian and 80 han patients. The incidence, number, and distribution of CMBs were compared between groups. Logistic regression was used to identify risk factors for the occurrence of cerebral hemorrhage.Results: The detection rate of CMBs was significantly lower in Mongolian patients compared to Han patients (P = 0.040). Mongolian patients had a higher distribution of CMBs in the deep or infratentorial regions (66.6% vs 58.1%), while Han patients had a higher lobar distribution (P = 0.007). Prolonged antiplatelet therapy (over 3 years) was a risk factor for CMB development in both groups and was also linked to an increased risk of ICH. Patients with a higher number of CMBs had a greater likelihood of experiencing ICH.Conclusion: Mongolian patients had a lower likelihood of developing CMBs than Han patients, but with a higher deep or infratentorial distribution. The presence of CMBs, especially with long-term antiplatelet therapy, is a significant predictor of ICH. No significant difference in ICH risk was found between ethnic groups. Close monitoring of patients with CMBs during prolonged antiplatelet therapy is crucial to reduce hemorrhagic events.Keywords: cerebral microbleeds, antiplatelet drugs, intracerebral hemorrhage, white matter hyperintensities
