Nature Communications (Apr 2024)

Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers

  • Min Pyeong Kim,
  • Swatilekha Kayal,
  • Chiwon Hwang,
  • Jonghoon Bae,
  • Hyunseok Kim,
  • Dong Gyu Hwang,
  • Min Ho Jeon,
  • Jeong Kon Seo,
  • Dowon Ahn,
  • Wonjoo Lee,
  • Sangwon Seo,
  • Joong-Hyun Chun,
  • Youngchang Yu,
  • Sung You Hong

DOI
https://doi.org/10.1038/s41467-024-47567-z
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 9

Abstract

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Abstract The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. In this work, we report an example of a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated. The oligosulfate sequences are determined by high resolution mass spectrometry of the hydrolyzed fragments, and polysulfate periodic copolymers are synthesized by using oligomeric bisfluorosulfates in a bi-directional fashion. The synthetic utility of this iterative ligation is demonstrated by preparing crosslinked network polymers as synthetic adhesive materials.