Einstein (São Paulo) ()

Polyclonal anti T-lymphocyte antibody therapy monitoring in kidney transplant recipients: comparison of CD3+ T cell and total lymphocyte counts

  • Fabiani Palagi Machado,
  • Alessandra Rosa Vicari,
  • Fábio Spuldaro,
  • João Batista Saldanha de Castro Filho,
  • Roberto Ceratti Manfro

DOI
https://doi.org/10.31744/einstein_journal/2018ao4278
Journal volume & issue
Vol. 16, no. 4

Abstract

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ABSTRACT Objective: To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. Methods: A single-center, retrospective study involving 226 patients submitted to kidney transplant between 2008 and 2013, and treated with anti-thymocyte globulin for induction or treatment of cellular rejection. Doses were adjusted according to CD3+ T cell or total lymphocyte counts in peripheral blood. Results: A total of 664 paired samples were analyzed. The Spearman's correlation coefficient was 0.416 (p20 cells/mm3. Conclusion: Total lymphocyte and CD3+ T cell counts in peripheral blood are not equivalent monitoring strategies in anti-thymocyte globulin therapy.

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