Nature Communications (Mar 2022)
Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis
- Mingming Wu,
- Xiao Zhang,
- Weijie Zhang,
- Yi Shiou Chiou,
- Wenchang Qian,
- Xiangtian Liu,
- Min Zhang,
- Hong Yan,
- Shilan Li,
- Tao Li,
- Xinghua Han,
- Pengxu Qian,
- Suling Liu,
- Yueyin Pan,
- Peter E. Lobie,
- Tao Zhu
Affiliations
- Mingming Wu
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Xiao Zhang
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Weijie Zhang
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Yi Shiou Chiou
- Tsinghua-Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School
- Wenchang Qian
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Xiangtian Liu
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Min Zhang
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Hong Yan
- Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Shilan Li
- Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Tao Li
- Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University
- Xinghua Han
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Pengxu Qian
- Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences and Institute of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
- Suling Liu
- Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences, Shanghai Medical College, Key Laboratory of Breast Cancer in Shanghai, Innovation Center for Cell Signaling Network, Cancer Institute, Fudan University
- Yueyin Pan
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Peter E. Lobie
- Tsinghua-Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School
- Tao Zhu
- The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- DOI
- https://doi.org/10.1038/s41467-022-29018-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The contribution of breast cancer stem cells (BCSCs) to metastasis needs further elucidation. Here, the authors show that BCSCs secrete DKK1 to protect metastasizing cancer cells from ferroptosis via upregulation of SLC7A11, and further show that the combination of a ferroptosis inducer with a DKK1 inhibitor reduces metastasis.
