Chemistry, Bioactivity, and Prediction of the Quality Marker (Q-Marker) of <i>Ferula</i> Plants in China: A Review
Yerlan Bahetjan,
Muguli Muhaxi,
Kejian Pang,
Murat Kizaibek,
Hui Tang,
Fatemeh Sefidkon,
Xinzhou Yang
Affiliations
Yerlan Bahetjan
International Cooperation Base for Active Substances in Traditional Chinese Medicine in Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, 182 Min-Zu Road, Wuhan 430074, China
Muguli Muhaxi
College of Biological and Geographical Sciences, Yili Normal University, Yining 835000, China
Kejian Pang
College of Biological and Geographical Sciences, Yili Normal University, Yining 835000, China
Murat Kizaibek
Traditional Kazakh Medicine Research Institute of Ili Kazakh Autonomous Prefecture, Yining 835000, China
Hui Tang
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Pharmacy School, Shihezi University, Shihezi 832003, China
Fatemeh Sefidkon
Research Division of Medicinal Plants, Research Institute of Forests and Rangelands, Agricultural Research Education and Extension Organization (AREEO), Tehran P.O. Box 13185-116, Iran
Xinzhou Yang
International Cooperation Base for Active Substances in Traditional Chinese Medicine in Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, 182 Min-Zu Road, Wuhan 430074, China
The genus of Ferula belongs to the family Apiaceae, and many Ferula plants are used as traditional Chinese medicines. Ferula plants were initially identified as early as the “Newly Revised Materia Medica” written in the Tang Dynasty (AD 659), and several of them are also recognized as the traditional medicines of the Uygur, Kazakh, and Mongolian. Ferula plants are distributed in China, Russia, India, Africa, Central Asia, and other places. Currently, the chemical components derived from Ferula plants are mainly coumarins, sesquiterpenes, and volatile oils. Ferula plants can exhibit diverse pharmacological activities such as anti-allergy, analgesia, relieving cough, anticoagulation, and anti-tumor. Therefore, this article summarized the domestic research conducted on the genus Ferula, appropriately combines the research status of the foreign genus Ferula, and describes the chemical composition, biological activity, toxicity issues, and Q-marker prediction. In addition, all the related studies about the genus Ferula are summarized by analyzing the various databases such as CNKI, Wanfang data, PubChem and SciFinder.
