Nature Communications (Jun 2018)
Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory
Abstract
Activity-dependent gene expression is thought to involve translocation of Ca2+/calmodulin (CaM) to the nucleus. Here, the authors examine a translocation-deficient mutant of γCaMKII, a Ca2+/CaM shuttle protein, to show that translocation of Ca2+/CaM is required for memory and synaptic plasticity.