Nature Communications (Jun 2018)

Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory

  • Samuel M. Cohen,
  • Benjamin Suutari,
  • Xingzhi He,
  • Yang Wang,
  • Sandrine Sanchez,
  • Natasha N. Tirko,
  • Nataniel J. Mandelberg,
  • Caitlin Mullins,
  • Guangjun Zhou,
  • Shuqi Wang,
  • Ilona Kats,
  • Alejandro Salah,
  • Richard W. Tsien,
  • Huan Ma

DOI
https://doi.org/10.1038/s41467-018-04705-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Activity-dependent gene expression is thought to involve translocation of Ca2+/calmodulin (CaM) to the nucleus. Here, the authors examine a translocation-deficient mutant of γCaMKII, a Ca2+/CaM shuttle protein, to show that translocation of Ca2+/CaM is required for memory and synaptic plasticity.