MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience

Yoichi Muramoto; Naoya Murakami; Tatsuki Karino; Satoru Sugimoto; Jun Takatsu; Masaki Oshima; Yasuo Kosugi; Terufumi Kawamoto; Takashi Hirayama; Kazunari Fujino; Yasuhisa Terao; Naoto Shikama

Clinical and Translational Radiation Oncology (Sep 2023)

MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience

Yoichi Muramoto,
Naoya Murakami,
Tatsuki Karino,
Satoru Sugimoto,
Jun Takatsu,
Masaki Oshima,
Yasuo Kosugi,
Terufumi Kawamoto,
Takashi Hirayama,
Kazunari Fujino,
Yasuhisa Terao,
Naoto Shikama

Affiliations

Yoichi Muramoto: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Naoya Murakami: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan; Corresponding author.
Tatsuki Karino: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Satoru Sugimoto: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Jun Takatsu: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Masaki Oshima: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Yasuo Kosugi: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Terufumi Kawamoto: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Takashi Hirayama: Department of Obstetrics and Gynecology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Kazunari Fujino: Department of Obstetrics and Gynecology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Yasuhisa Terao: Department of Obstetrics and Gynecology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Naoto Shikama: Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan

Journal volume & issue: Vol. 42
p. 100659

Abstract

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We first used MucoUp®, a hyaluronic acid used in endoscopic resection, as a spacer in brachytherapy. In five cervical cancer patients, MucoUp® insertion increased a 90% dose of the high-risk CTV to over 80 Gy while decreasing the dose of organs at risk. No related adverse events were observed.

Published in Clinical and Translational Radiation Oncology

ISSN: 2405-6308 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/clinical-and-translational-radiation-oncology

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