Nature Communications (Jun 2016)
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation
- Luise Hartmann,
- Sayantanee Dutta,
- Sabrina Opatz,
- Sebastian Vosberg,
- Katrin Reiter,
- Georg Leubolt,
- Klaus H. Metzeler,
- Tobias Herold,
- Stefanos A. Bamopoulos,
- Kathrin Bräundl,
- Evelyn Zellmeier,
- Bianka Ksienzyk,
- Nikola P. Konstandin,
- Stephanie Schneider,
- Karl-Peter Hopfner,
- Alexander Graf,
- Stefan Krebs,
- Helmut Blum,
- Jan Moritz Middeke,
- Friedrich Stölzel,
- Christian Thiede,
- Stephan Wolf,
- Stefan K. Bohlander,
- Caroline Preiss,
- Linping Chen-Wichmann,
- Christian Wichmann,
- Maria Cristina Sauerland,
- Thomas Büchner,
- Wolfgang E. Berdel,
- Bernhard J. Wörmann,
- Jan Braess,
- Wolfgang Hiddemann,
- Karsten Spiekermann,
- Philipp A. Greif
Affiliations
- Luise Hartmann
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Sayantanee Dutta
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Sabrina Opatz
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Sebastian Vosberg
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Katrin Reiter
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Georg Leubolt
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Klaus H. Metzeler
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Tobias Herold
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Stefanos A. Bamopoulos
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Kathrin Bräundl
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Evelyn Zellmeier
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Bianka Ksienzyk
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Nikola P. Konstandin
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Stephanie Schneider
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Karl-Peter Hopfner
- Department of Biochemistry, Ludwig-Maximilians-Universität (LMU) München
- Alexander Graf
- Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität (LMU) München
- Stefan Krebs
- Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität (LMU) München
- Helmut Blum
- German Cancer Consortium (DKTK)
- Jan Moritz Middeke
- German Cancer Consortium (DKTK)
- Friedrich Stölzel
- German Cancer Consortium (DKTK)
- Christian Thiede
- German Cancer Consortium (DKTK)
- Stephan Wolf
- German Cancer Research Center (DKFZ)
- Stefan K. Bohlander
- Department of Molecular Medicine and Pathology, The University of Auckland
- Caroline Preiss
- Department of Transfusion Medicine, Cell Therapeutics and Hemostasis, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Linping Chen-Wichmann
- Department of Transfusion Medicine, Cell Therapeutics and Hemostasis, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Christian Wichmann
- Department of Transfusion Medicine, Cell Therapeutics and Hemostasis, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Maria Cristina Sauerland
- Institute of Biostatistics and Clinical Research, University of Münster
- Thomas Büchner
- Department of Medicine A, Hematology, Oncology and Pneumology, University of Münster
- Wolfgang E. Berdel
- Department of Medicine A, Hematology, Oncology and Pneumology, University of Münster
- Bernhard J. Wörmann
- Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Campus Virchow
- Jan Braess
- Oncology and Hematology, St. John-of-God Hospital
- Wolfgang Hiddemann
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Karsten Spiekermann
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- Philipp A. Greif
- Department of Internal Medicine 3, University Hospital, Ludwig-Maximilians-Universität (LMU) München
- DOI
- https://doi.org/10.1038/ncomms11733
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 7
Abstract
The t(8;21) translocation is often found in acute myeloid leukaemia but is not sufficient for development of the disease. In this study, the authors identify frequent mutations in the transcriptional repressor, ZBTB7A, in these patients and show that the mutations reduce DNA binding activity.
