Diagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinoma

Abstract

In 60 patients operated in stages III and IV of epithelial ovarian carcinoma continuous determination of CA 125 from serum was done during the following 2 years. The main condition for entering the survey were elevated values of CA 125 in serum > 35 U/mL and histologically verified epithelial ovarian carcinoma. The aim of the survey was to perform statistical assessment of serum CA 125 determination in diagnostics of recurrence and progression of the disease in stages III and IV of epithelial ovarian carcinoma, and percentage (%) of false positive and negative results. Determination of CA 125 from serum during 2 postoperative years is a reliable but not completely certain diagnostic parameter in detection of the disease progression in stages III and IV of epithelial ovarian carcinoma (sensitivity 79.3%, specificity 97.1%, positive predictive value 91.2%, negative predictive value 92.4%, test accuracy 92.1%). False positive (0.7%) and false negative results (4.7%) of individual tests were present in 5.4% of all samples.

Keywords

• ca 125
• ovarian carcinoma
• recurrence
• diagnostic importance